Gene scissors found to cause chaos in the genome of tomatoes

20 June 2023 / Recent scientific findings have revealed chromothripsis-like effects after the application of CRISPR/Cas in the genome of tomatoes. Chromothripsis refers to a phenomenon in which often several hundred genetic changes occur simultaneously in a 'catastrophic' event. Many sections of the genetic material can be swapped, twisted, recombined or even lost if this occurs.

It has been known for some time that ‘CRISPRthripsis’, which is another term for the above-described phenomenon, occurs in mammalian (and human) cells. This effect has now been also demonstrated in plants after gene scissor applications. The new study was already published during the peer-review process. The findings show that gene scissor applications cause unintended genetic alterations much more frequently than previously thought, affecting large parts of the genome.