According to the results of a case study on Brazil, the Swedish Institute for Food and Biotechnology confirmed that the need for plant protection and the number of resistant weeds has grown since the introduction of GM soy. There is also fear that some farmers are using outdated herbicides that are banned in Europe. The development of genetically engineered plants with multiple resistance offers no solution. The predominant use of GM soy in the main producing countries USA, Argentina and Brazil is characterized by its unilateral weed management and a lack of tillage. Both practices favor the formation of resistant weeds. From 2007 to 2009 the import from Europe to Brazil of highly toxic herbicide Paraquat has increased from 0 to 66 million kg. This indicates an increased use of the herbicide, which was banned in Europe since 2007. The Round Up Ready Plus Program by Monsanto shows that the manufacturers themselves are taking the resistance problem in weeds seriously. The company will pay for an additional herbicide application at planting of glyphosate-resistant GM soya. Even with multiple resistant GM soybeans, resistance problems will continue. This study recommends that the use of herbicides with different mechanisms of action should not be developed, as they are merely due to the monopoly position of GM soybean. Above all. alternative farming methods should be used.